Leiomyosarcoma of the Colon.
نویسندگان
چکیده
INTRODUCTION Gastrointestinal stromal tumors are the most common mesenchymal tumors of the digestive tract. Leiomyosarcomas of the gastrointestinal tract are rare mesenchymal neoplasms which grossly and histologically resemble gastrointestinal stromal tumors. They may be differentiated from gastrointestinal stromal tumors by using immunohistochemistry and they are typically positive for a smooth muscle actin and desmin and negative for c-kit, CD34 and DOG1.1. They often express calponin and h-caldesmon. CASE REPORT We present a case of a 59-year-old male with anemia, weight loss, intermittent abdominal pain and right abdominal mass. Colonoscopy revealed an exophytic ulcerated neoplastic mass in the ascending colon and abdominal computed tomography scan showed an ill-defined heterogeneous tumor mass which surrounded almost the whole ascending colon. The patient underwent right hemicolectomy and partial resection of ileum. Histopathological examination revealed a leiomyosarcoma composed of atypical spindle cells positive for a smooth muscle actin, desmin and vimentin, and negative for c-kit, CD34, S100 and neuron specific enolase. The patient is alive 8 months after the operation, undergoing chemotherapy. CONCLUSION We have concluded that the multimodal approach comprising chemotherapy and complete surgical resection controls the leiomyosarcomas.
منابع مشابه
In this report, we present the case of a patient who underwent curative surgery for leiomyosarcoma arising in the descending mesocolon and for a metachronous liver metastasis, together with the clinicopathological findings and a literature review. Case report
Mesenteric leiomyosarcoma is a rare disease with poor prognosis. Previously, mesenteric leiomyosarcoma was not differentiated from gastrointestinal stromal tumor (GIST), which is the most common mesenchymal tumor of the gastrointestinal tract, and several cases of GIST may have been misclassified as mesenteric leiomyosarcoma. Thus, the actual clinicopathological characteristics of mesenteric le...
متن کاملAuthor's response to reviews Title: Leiomyosarcoma of sigmoid colon with multiple liver metastases and gastric cancer: case report
متن کامل
Recurrent Renal Leiomyosarcoma Mimicking a Colonic Submucosal Tumor: A Case Report
A primary leiomyosarcoma of the kidney is a rare, but highly aggressive, neoplasm, accounting for only 0.1% of all invasive renal tumors. Local or systemic recurrence is common, but a leiomyosarcoma is difficult to diagnose preoperatively. We recently encountered an interesting case of an unusual recurrence of a renal leiomyosarcoma. A 57-year-old woman visited our hospital complaining of lower...
متن کاملLeiomyosarcoma of the sigmoid colon with biorherapy
Background: Leiomyosarcoma (LMS) of sigmoid colon is an extremely rare neoplasm with poor prognosis, which is often misdiagnosed as colonic adenocarcinoma. The diagnosis of LMS depends on the pathology. The mitosis and the histological grade observation are important for diagnosis. Unlike gastrointestinal stromal tumor, c-KIT in LMS is negative, and immunohistochemistry examination is positive ...
متن کاملA Rare Case of Colonic Leiomyosarcoma in Association with Ulcerative Colitis
Ulcerative colitis (UC) is known to be associated with an increased risk of colorectal cancer. However, the occurrence of non-epithelial malignancies is uncommon. An elevated lesion in the descending colon was found in a 51-year-old woman with a 30-year history of UC. Despite tumor progression, repeated biopsies showed no cancerous findings. Because the lesion was highly suspected to be a malig...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Medicinski pregled
دوره 68 11-12 شماره
صفحات -
تاریخ انتشار 2015